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The study focused on widely prescribed agents including semaglutide and tirzepatide, which have seen rapid uptake in both type 2 diabetes management and weight reduction

Here, we discovered that cocaine self-administration and acute withdrawal decreased plasma GLP-1 levels and that chemogenetic activation of GLP-1-producing NTS neurons that project to the VTA is sufficient to attenuate cocaine seeking during abstinence

Appetite suppression is usually strong, and weight loss of one to two pounds per week becomes common with proper dietary adherence

Here's a breakdown of what they are and how they work: What is Semaglutide

Important research boundary: These clinical trial results were achieved with FDA-approved branded medications studied under controlled conditions with specific manufacturing processes, quality controls, and dosing protocols